NCIt definition : An immunoglobulin G4 (IgG4) bispecific antibody composed of two single-chain variable
fragments (scFv), one directed against the tumor-associated antigen (TAA) human prostate-specific
membrane antigen (PSMA), fused to one that is directed against the CD3 antigen found
on T-lymphocytes, with potential immunostimulating and antineoplastic activities.
Upon administration, voxalatamab simultaneously binds to both CD3 on cytotoxic T-lymphocytes
(CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects
CTLs to PSMA-expressing tumor cells, which results in the CTL-mediated cell death
of PSMA-expressing tumor cells. PSMA, a tumor associated antigen, is overexpressed
on the surface of metastatic and hormone-refractory prostate cancer cells.;
UNII : O257GFG7G0;
CAS number : 2411871-58-2;
Molecule name : JNJ-63898081; JNJ 63898081; JNJ-8081;
Semantic type(s)