Preferred Label : Copper Cu 64 Zadavotide Guraxetan;
NCIt synonyms : Copper Cu 64 PSMA-I&T; 64Cu-PSMA I&T; Copper Cu 64-PSMA-I&T;
NCIt related terms : COPPER CU-64 ZADAVOTIDE GURAXETAN;
NCIt definition : A radioconjugate composed of zadavotide guraxetan, a human prostate-specific membrane
antigen (PSMA)-targeting ligand linked to the bifunctional, macrocyclic chelating
agent 1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA;
DOTA-GA), labeled with the positron emission tomography (PET) tracer copper Cu 64,
with potential use as a tracer for PSMA-expressing tumors during positron emission
tomography (PET)/computed tomography (CT). Upon administration, copper Cu 64 zadavotide
guraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing
tumor cells can be detected during PET/CT imaging. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
UNII : JN9XS4J584;
CAS number : 2923916-20-3;
NCI Metathesaurus CUI : CL1912568;
Origin ID : C192225;
UMLS CUI : C5784995;
Semantic type(s)
- concept_is_in_subset
- has_target
