Preferred Label : Copper Cu 64-PSMA-I&T;
NCIt synonyms : Copper Cu 64 PSMA-I&T; 64Cu-PSMA I&T;
NCIt definition : A radioconjugate composed of PSMA-I&T, a human prostate-specific membrane antigen
(PSMA)-targeting ligand linked to the bifunctional, macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1-(glutamic
acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA), labeled with the positron emission
tomography (PET) tracer copper Cu 64, with potential use as a tracer for PSMA-expressing
tumors during positron emission tomography (PET)/computed tomography (CT). Upon administration
of copper Cu 64-PSMA-I&T, PSMA-I&T targets and binds to PSMA-expressing tumor cells.
Upon binding, PSMA-expressing tumor cells can be detected during PET/CT imaging. PSMA,
a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed on
the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells
as well as a variety of other solid tumors.;
NCI Metathesaurus CUI : CL1912568;
Origin ID : C192225;
UMLS CUI : C5784995;
Semantic type(s)
- concept_is_in_subset
- has_target
