Preferred Label : 99mTc-based PSMA Imaging and Surgery Agent;
NCIt synonyms : 99mTc-DOTAGA-(3-iodo-y)-f-k-Sub(KuE); 99mTc-labeled PSMA-targeting I&S SPECT/CT Agent; Technetium Tc99m PSMA-targeting Agent I&S; 99mTc-based PSMA for Imaging and Surgery;
NCIt definition : A diagnostic radioconjugate composed of a prostate-specific membrane antigen (PSMA)-targeting
ligand that is linked, via the bifunctional, macrocyclic chelating agent 1,4,7,10-tetraazacyclododecane-1-(glutamic
acid)-4,7,10-triacetic acid (DOTAGA; DOTA-GA), to the radioisotope technetium Tc 99m
(Tc99m), that can potentially be used as a radioimaging agent for radio-guided surgery
upon single-photon emission computed tomography (SPECT)/computed tomography (CT) for
PSMA-overexpressing tumor cells. Upon administration, 99mTc-based PSMA-imaging and
surgery (I&S agent targets and binds to PSMA on PSMA-expressing tumor cells. Upon
SPECT/CT imaging, PSMA-expressing tumors can be visualized and identified. PSMA, a
tumor-associated antigen (TAA), is overexpressed by most prostate cancers.;
NCI Metathesaurus CUI : CL1647652;
Origin ID : C178154;
UMLS CUI : C5554865;
Semantic type(s)
- concept_is_in_subset
- has_target
