" /> Nezastomig - CISMeF





Preferred Label : Nezastomig;

NCIt synonyms : Anti-PSMA/Anti-CD28 Bispecific Antibody REGN5678; Anti-PSMAxCD28 Antibody REGN5678; Anti-PSMA/CD28 Bispecific Antibody REGN5678;

NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) prostate-specific membrane antigen (PSMA) and the co-stimulatory T-cell-specific surface glycoprotein CD28, with potential immunostimulating and antineoplastic activities. Upon administration of nezastomig this bispecific antibody binds to both CD28 on cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This activates and redirects CTLs to PSMA-expressing tumor cells, which may result in the CTL-mediated cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of metastatic and hormone-refractory prostate cancer cells.;

UNII : M355PGI1TG;

CAS number : 2657613-60-8;

Molecule name : REGN-5678; REGN 5678;

NCI Metathesaurus CUI : CL973295;

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05/07/2025


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