Preferred Label : Actinium Ac 225 PSMA-R2;
NCIt synonyms : [225Ac]Ac-PSMA-R2; 225Ac-labeled PSMA-R2; Actinium (225Ac) PSMA-R2; Ac225-PSMA-R2; 225AcPSMA-R2; 225Ac-PSMA-R2; Actinium-225 PSMA-R2;
NCIt definition : A radioconjugate composed of PSMA-R2, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the alpha-emitting radioisotope actinium Ac 225, with potential
antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration
of 225Ac-PSMA-R2, the PSMA-R2 moiety targets and binds to PSMA-expressing tumor cells.
Upon binding, PSMA-expressing tumor cells are destroyed by a cytotoxic dose of alpha
radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein,
is expressed on the membrane of prostatic epithelial cells and overexpressed on the
majority of prostate tumor cells.;
Origin ID : C215796;
concept_is_in_subset
- has_target
