Preferred Label : Copper Cu 64 NOTA-PSMAi-PEG-Cy5.5-C' Dots;
NCIt synonyms : 64Cu-NOTA-PSMA-PEG-Cy5.5-C' Dot Tracer; 64Cu-NOTA-PSMA-PEG-Cy5.5-C' Dots; (64Cu)-labeled PSMA-targeting -PEG Cy5.5-C' Dots; 64Cu-NOTA-PSMAi-PEG-Cy5.5-C' Dots;
NCIt definition : An imaging agent composed of silica-based nanoparticles labeled with a near-infrared
(NIR) fluorophore, cyanine 5.5 (Cy5.5), and surrounded by polyethylene glycol (PEG)
chains attached to a human prostate-specific membrane antigen (PSMA) inhibitor (PSMAi)
and labeled with, via the macrocyclic chelating agent 1,4,7-triazacyclononane-N,N',N''-triacetic
acid (NOTA), the radioisotope copper Cu 64, with potential tumor-selective diagnostic
properties upon positron emission tomography (PET) imaging. Upon administration of
the copper Cu 64 NOTA-PSMAi-PEG-Cy5.5-C' dots, the PSMAi moiety selectively targets
and binds to PSMA expressed on tumor cells. Upon PET imaging, PSMA-expressing tumor
cells can be visualized and assessed. PSMA, a tumor-associated antigen (TAA) and type
II transmembrane protein, is expressed on the membrane of prostatic epithelial cells
and overexpressed on prostate tumor cells. The nanoparticle formulation may allow
for enhanced uptake in PSMA-positive tumors.;
NCI Metathesaurus CUI : CL979186;
Origin ID : C166169;
UMLS CUI : C5237750;
Semantic type(s)
- concept_is_in_subset
- has_target
