NCIt definition : A preparation of T-lymphocytes that are genetically engineered to express a fourth-generation
chimeric antigen receptor (4SCAR) targeting the two tumor-associated antigens (TAAs)
prostate-specific membrane antigen (PSMA) and CD70 (CD27 ligand; tumor necrosis factor
superfamily member 7; TNFSF7), with potential immunostimulating and antineoplastic
activities. Upon administration, the anti-PSMA/anti-CD70 4SCAR-expressing bispecific
T-cells are directed to and induce selective toxicity in PSMA- and CD70-expressing
tumor cells. PSMA, a type II transmembrane protein, is expressed on the membrane of
prostatic epithelial cells and overexpressed on prostate tumor cells as well as a
variety of other solid tumors, including brain tumor, neuroblastoma and some lymphoma
tumor tissues. CD70, a cytokine belonging to the tumor necrosis superfamily (TNFSF)
and the ligand for the costimulatory receptor CD27, is expressed on the surfaces of
various types of cancer cells; its overexpression may play an important role in the
evasion of immune surveillance.;