NCIt definition : A half-life extended (HLE), bispecific T-cell engager (BiTE) antibody composed of
two single-chain variable fragments (scFv), one directed against the tumor-associated
antigen (TAA) human prostate-specific membrane antigen (PSMA), fused to one that is
directed against the CD3 antigen found on T-lymphocytes, with potential immunostimulating
and antineoplastic activities. Upon administration acapatamab binds to both CD3 on
cytotoxic T-lymphocytes (CTLs) and PSMA found on PSMA-expressing tumor cells. This
activates and redirects CTLs to PSMA-expressing tumor cells, which results in the
CTL-mediated cell death of PSMA-expressing tumor cells. PSMA, a tumor associated antigen,
is overexpressed on the surface of metastatic and hormone-refractory prostate cancer
cells.;
Semantic type(s)