Preferred Label : Actinium Ac 225 Rosopatamab Tetraxetan;
NCIt synonyms : Ac 225 MOAB J591; 225Ac-J591; Ac 225 Monoclonal Antibody J591; Actinium Ac-225 Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591; Actinium Ac-225 Anti-PSMA Monoclonal Antibody J591;
NCIt definition : A radioimmunoconjugate consisting of a humanized monoclonal antibody directed against
prostate specific membrane antigen (PSMA) labeled with the alpha particle-emitting
radioisotope actinium Ac-225, with potential antineoplastic activity. Upon administration,
actinium Ac 225 rosopatamab tetraxetan binds to the extracellular domain of PSMA with
high affinity, thereby delivering alpha radiation to PSMA expressing cells. PSMA,
a type II membrane protein expressed in all types of prostatic tissues, is often overexpressed
in tumor cells.;
NCI Metathesaurus CUI : CL554298;
Origin ID : C153159;
UMLS CUI : C4727063;
Semantic type(s)
- concept_is_in_subset
- has_target
