NCIt definition : A radioimmunoconjugate comprised of an antibody fragment (IAB2M) against prostate-specific
membrane antigen (PSMA), conjugated to the chelator desferrioxamine (Df) and labeled
with the radioisotope zirconium Zr 89, with potential positron emission tomography
(PET) imaging activity. Upon administration of zirconium Zr 89 Df-IAB2M, the antibody
moiety binds to the extracellular domain of PSMA expressed on cancer cells. This may
enable PET detection of the radioisotope moiety, and allows the imaging and quantification
of PSMA-expressing tumor cells. PSMA is a cell surface peptidase highly expressed
by malignant prostate epithelial cells and vascular endothelial cells in various solid
tumor malignancies.;
Semantic type(s)