Anti-PSMA Monoclonal Antibody-MMAE Conjugate

Preferred Label : Anti-PSMA Monoclonal Antibody-MMAE Conjugate;

NCIt synonyms : Anti-PSMA Monoclonal Antibody-Monomethylauristatin E Conjugate; PSMA ADC; Anti-PSMA-MMAE-ADC; Prostate-specific Membrane Antigen Antibody-Drug Conjugate;

NCIt definition : An antibody-drug conjugate (ADC) containing a fully human monoclonal antibody directed against prostate-specific membrane antigen (PSMA), conjugated via a stable, enzyme-cleavable linker to monomethylauristatin E (MMAE), an auristatin derivative and a potent microtubule inhibitor, with potential antineoplastic activity. The monoclonal antibody moiety of this conjugate selectively binds to PSMA, a protein which is abundantly expressed on the surface of metastatic and hormone-refractory prostate cancer cells. Upon internalization and proteolytic cleavage, MMAE binds to tubulin and inhibits its polymerization, resulting in G2/M phase arrest and tumor cell apoptosis.;

Details

Origin ID

C95707;

UMLS CUI

C2987347;

Currated CISMeF NLP mapping
- PSMA ADC [MeSH concept]
- PSMA ADC [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- PSMA ADC [MeSH Supplementary Concept]
- PSMA ADC [MeSH concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glutamate Carboxypeptidase 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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