Preferred Label : Anti-PSMA/PBD ADC MEDI3726;
NCIt synonyms : ADC MEDI3726;
NCIt related terms : MEDI-3726;
NCIt definition : An antibody-drug conjugate (ADC) consisting of an engineered version of anti-human
prostate-specific membrane antigen (PSMA) monoclonal antibody J591 conjugated, via
a valine-alanine dipeptide linker, to tesirine, a cytotoxic, DNA minor groove crosslinking
agent and pyrrolobenzodiazepine (PBD) dimer, with potential antineoplastic activity.
Upon administration of anti-PSMA/PBD ADC MEDI3726, the antibody moiety targets the
cell surface antigen PSMA, which is found on prostate cancer cells. Upon antibody/antigen
binding, internalization and lysosome-mediated cleavage of the dipeptide linker, the
cytotoxic PBD moiety is released. In turn, the imine groups of the PBD moiety bind
to the N2 positions of guanines on opposite strands of DNA. This induces DNA strand
breaks, inhibits DNA replication, leads to G2/M cell cycle arrest, induces cell death,
and inhibits the proliferation of PSMA-overexpressing tumor cells. PSMA is overexpressed
by prostate cancers; its expression is associated with poor prognosis and metastasis.;
UNII : SA4H7K0SW2;
Molecule name : ADCT-401; ADCT 401; MEDI 3726; MEDI-3726;
NCI Metathesaurus CUI : CL538618;
Origin ID : C140552;
UMLS CUI : C4683044;
Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
- has_target
