PSMA/TARP Peptide Vaccine

Preferred Label : PSMA/TARP Peptide Vaccine;

NCIt synonyms : PSMA TARP Peptide Vaccine;

NCIt definition : A peptide-based cancer vaccine containing epitopes of T cell receptor gamma-chain alternate reading frame protein (TARP) and prostate-specific membrane antigen (PSMA) in combination with a Poly IC-LC immunoadjuvant, with potential antineoplastic activity. Upon administration, PSMA/TARP peptide vaccine may stimulate a host cytotoxic T-cell (CTL) response against TARP- and PSMA-expressing tumor cells, resulting in tumor cell cytotoxicity. The nuclear protein TARP and PSMA are commonly expressed in prostate cancer cells.;

NCI Metathesaurus CUI : CL387733;

Details

Origin ID

C78819;

UMLS CUI

C2698701;

Semantic type(s)
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Sensitization [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glutamate Carboxypeptidase 2 [NCIt concept]
- T-Cell Receptor Gamma Chain Alternative Reading Frame Protein Isoform 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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