Preferred Label : PSMA-targeting Agent-Technetium Tc99m EC0652;
NCIt synonyms : DUPA-99mTc EC0652; DUPA-99mTc; 99mTc-EC0652; Radiodiagnostic EC0652;
NCIt related terms : EC-0652;
NCIt definition : A radioconjugate composed of 2-[3-(1, 3-dicarboxy propyl)-ureido] pentanedioic acid
(DUPA), a prostate-specific membrane antigen (PSMA)-targeting ligand, linked to the
radioisotope technetium Tc 99m (Tc99m), that can potentially be used as a radioimaging
agent for PSMA-overexpressing tumor cells. Upon administration, the PSMA-targeting
moiety of EC0652 targets and binds to PSMA-expressing tumors. Upon uptake and single-photon
emission computed tomography (SPECT) imaging, PSMA-expressing tumors can be visualized
and identified. In turn, PSMA-overexpression can be used to evaluate both the efficacy
of and response to certain PSMA-targeting cytotoxic agents. PSMA, a tumor-associated
antigen (TAA), is overexpressed by most prostate cancers.;
UNII : RWY5U5KZV3;
CAS number : 1025066-50-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1025066-50-5
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : EC0652; EC 0652;
NCI Metathesaurus CUI : CL524580;
Origin ID : C136776;
UMLS CUI : C4526971;
Semantic type(s)
- concept_is_in_subset
- has_target
