Preferred Label : Actinium Ac 225 Zadavotide Guraxetan;
NCIt synonyms : Actinium Ac 225-labeled PSMA-I&T; 225Ac-PSMA I&T; Actinium Ac 225 PSMA-I&T;
NCIt related terms : ACTINIUM ZADAVOTIDE GURAXETAN ACTINIUM AC-225;
NCIt definition : A radioconjugate composed of zadavotide guraxetan, a human prostate-specific membrane
antigen (PSMA)-targeting ligand linked to the bifunctional tmacrocyclic chelating
agent 1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA;
DOTA-GA), and conjugated to the alpha-emitting radioisotope actinium Ac 225, with
potential antineoplastic activity. Upon administration, actinium Ac 225 zadavotide
guraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, the radioisotope
moiety delivers a cytotoxic dose of alpha radiation to PSMA-expressing tumor cells.
PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is expressed
on the membrane of prostatic epithelial cells and overexpressed on prostate tumor
cells as well as a variety of other solid tumors.;
UNII : WAW9659ZJD;
CAS number : 2901793-42-6;
NCI Metathesaurus CUI : CL1915070;
Origin ID : C200790;
UMLS CUI : C5856411;
Semantic type(s)
- concept_is_in_subset
- has_target
