Preferred Label : Actinium Ac 225 PSMA-I&T;
NCIt synonyms : Actinium Ac 225-labeled PSMA-I&T; 225Ac-PSMA I&T;
NCIt definition : A radioconjugate composed of PSMA-I&T, a human prostate-specific membrane antigen
(PSMA)-targeting ligand that is linked via the bifunctional tmacrocyclic chelating
agent 1,4,7,10-tetraazacyclododecane-1-(glutamic acid)-4,7,10-triacetic acid (DOTAGA;
DOTA-GA), to the alpha-emitting radioisotope actinium Ac 225, with potential antineoplastic
activity. Upon administration of actinium Ac 225 PSMA-I&T, PSMA-I&T targets and binds
to PSMA-expressing tumor cells. Upon binding, the radioisotope moiety delivers a cytotoxic
dose of alpha radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
Origin ID : C200790;
concept_is_in_subset
- has_target
