Preferred Label : Copper Cu 64-DOTA-TLX592;
NCIt synonyms : 64Cu-DOTA-TLX592; 64Cu-TLX592;
NCIt definition : A radioimmunoconjugate containing an engineered monoclonal antibody targeting the
tumor-associated antigen (TAA) human prostate-specific membrane antigen (PSMA), conjugated
with the bifunctional, macrocyclic chelating agent tetra-azacyclododecanetetra-acetic
acid (DOTA), and labeled with the radioisotope copper Cu 64, with potential diagnostic
properties upon positron emission tomography (PET) imaging. Upon administration of
copper Cu 64-DOTA-TLX592, the monoclonal antibody moiety TLX592 targets and specifically
binds to PSMA on tumor cells. Upon binding, the radioisotope moiety may be detected
using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor
cells and the biodistribution of TLX592. PSMA is overexpressed on the surface of metastatic
and hormone-refractory prostate cancer cells.;
NCI Metathesaurus CUI : CL1661918;
Origin ID : C179253;
UMLS CUI : C5555554;
Semantic type(s)
- concept_is_in_subset
- has_target
