Preferred Label : Lutetium Lu 177 DOTA-N3-CTT1403;
NCIt synonyms : 177Lu-DOTA-N3-CTT1403; Lutetium Lu 177 DOTA-azide-CTT1403; 177Lu-DOTA-azide-CTT1403;
NCIt definition : A radioconjucate consisting of CTT1403, a phosphoramidate-based irreversible inhibitor
of human prostate-specific membrane antigen with an albumin binding moiety, connected
via click chemistry to lutetium Lu 177-dodecanetetraacetic acid-azide (177Lu-DOTA-N3),
with potential antineoplastic activity. Upon administration, lutetium Lu 177-DOTA-N3-CTT1403
targets and binds to PSMA expressed on tumor cells via its CTT1403 moiety, and upon
internalization, delivers cytotoxic beta radiation directly to PSMA-expressing tumor
cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein, is
expressed on the membrane of prostatic epithelial cells and overexpressed on most
prostate tumor cells. The albumin binding motif extends circulation half-life thereby
improving tumor cell uptake of the radioconjugate.;
NCI Metathesaurus CUI : CL937593;
Origin ID : C158044;
UMLS CUI : C4764005;
Semantic type(s)
- concept_is_in_subset
- has_target
