Preferred Label : Lutetium Lu 177 PSMA-EB-01;
NCIt synonyms : 177Lu-PSMA-EB-01; Lutetium Lu 177-labeled PSMA-EB-01;
NCIt definition : A radioconjugate composed of PSMA-EB-01, a human prostate-specific membrane antigen
(PSMA)-targeting ligand conjugated to the Evans blue (EB) moiety, and linked to the
beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic
activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium
Lu 177 PSMA-EB-01, PSMA-EB-01 targets and binds to PSMA-expressing tumor cells. Upon
binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery
of beta particle radiation. PSMA, a tumor-associated antigen (TAA) and type II transmembrane
protein, is expressed on the membrane of prostatic epithelial cells and overexpressed
on prostate tumor cells as well as a variety of other solid tumors. The EB moiety
of PSMA-EB-01 binds to serum albumin, which extends its circulation half-life. This
may improve tumor uptake and efficacy of the agent.;
NCI Metathesaurus CUI : CL1913095;
Origin ID : C193469;
UMLS CUI : C5785778;
Semantic type(s)
- concept_is_in_subset
- has_target
