Preferred Label : Lutetium Lu-177 PSMA-R2;
NCIt synonyms : Lu177-PSMA-R2; 177LuPSMA-R2; Lutetium-177 PSMA-R2; 177Lu-PSMA-R2;
NCIt definition : A radioconjugate composed of PSMA-R2, a human prostate-specific membrane antigen (PSMA)-targeting
ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with
potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous
administration of 177Lu-PSMA-R2, the PSMA-R2 moiety targets and binds to PSMA-expressing
tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through
the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen
(TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on the majority of prostate tumor cells.;
NCI Metathesaurus CUI : CL552202;
Origin ID : C150467;
UMLS CUI : C4725757;
Semantic type(s)
- concept_is_in_subset
- has_target
