NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) prostate-specific
membrane antigen (PSMA) and the co-stimulatory T-cell-specific surface glycoprotein
CD28, with potential immunostimulating and antineoplastic activities. Upon administration,
anti-PSMA/anti-CD28 bispecific antibody JNJ-87189401 binds to both CD28 expressed
on cytotoxic T-lymphocytes (CTLs) and PSMA expressed on tumor cells. This activates
and redirects CTLs to PSMA-expressing tumor cells, which may result in the CTL-mediated
cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of
metastatic and hormone-refractory prostate cancer cells.;
Semantic type(s)