Preferred Label : Anti-PSMA/Anti-CD28 Bispecific Antibody JNJ-87189401;
NCIt synonyms : PSMA-CD28 Bispecific Antibody JNJ-87189401; PSMA x CD28 Bispecific Antibody JNJ-87189401; Anti-PSMA/CD28 Bispecific Antibody JNJ-87189401;
NCIt definition : A bispecific antibody directed against both the tumor-associated antigen (TAA) prostate-specific
membrane antigen (PSMA) and the co-stimulatory T-cell-specific surface glycoprotein
CD28, with potential immunostimulating and antineoplastic activities. Upon administration,
anti-PSMA/anti-CD28 bispecific antibody JNJ-87189401 binds to both CD28 expressed
on cytotoxic T-lymphocytes (CTLs) and PSMA expressed on tumor cells. This activates
and redirects CTLs to PSMA-expressing tumor cells, which may result in the CTL-mediated
cell death of PSMA-expressing tumor cells. PSMA is overexpressed on the surface of
metastatic and hormone-refractory prostate cancer cells.;
Molecule name : JNJ 87189401; JNJ-87189401;
Origin ID : C202466;
chemical_or_drug_has_mechanism_of_action
- concept_is_in_subset
- has_target
