Preferred Label : Indium In 111 Capromab Pendetide;
NCIt synonyms : 111-In Capromab Pendetide;
NCIt related terms : INDIUM IN-111 CAPROMAB PENDETIDE;
NCIt definition : A radioimmunoconjugate consisting of the murine IgG1 kappa monoclonal antibody capromab
(7E11-C5.3), conjugated to the linker-chelator glycyl-tyrosyl-(N,-diethylenetriaminepentaacetic
acid)-lysine hydrochloride (GYK-DTPA-HCl) and labeled with radioisotope indium In
111, with ligand-binding and gamma-emitting activities. Upon intravenous administration,
indium In 111-capromab pendetide binds to a cytoplasmic epitope of human prostate
specific membrane antigen (PSMA) expressed on prostate tumor cell surfaces via its
capromab moiety and, upon internalization, allows radioimmunolocalization with gamma
scintigraphy. PSMA is a cell surface glycoprotein abundantly expressed by prostate
epithelium and is typically overexpressed by prostate cancer cells.;