Preferred Label : DNA Vector pPRA-PSM Vaccine;
NCIt synonyms : DNA Plasmid Vector pPRA-PSM Vaccine; PRA-PSM-Expressing Plasmid;
NCIt definition : A cancer vaccine consisting of a DNA plasmid encoding epitopes of the human preferential
antigen of melanoma (PRAME) and the prostate specific membrane antigen (PSMA) with
potential immunostimulating activity. Upon direct administration of this vaccine into
lymph nodes, peptides expressed by DNA plasmid vector pPRA-PSM may activate the immune
system, resulting in a cytotoxic T-lymphocyte (CTL) response against PRAME- and PSMA-expressing
cells. PRAME and PSMA are tumor associated antigens upregulated in a number of cancer
cell types. As part of the MKC1106-PP regimen exploiting the 'prime-boost strategy',
this plasmid is responsible for priming the immune response and is used in conjunction
with a peptide vaccine consisting of PRAME and PSMA that boosts the immune system
against PRAME- and PSMA-expressing tumor cells.;
NCIt note : Part of the MKC1106-PP regimen together with Synthetic Peptides E-PRA and E-PSM;
NCI Metathesaurus CUI : CL376107;
Origin ID : C67089;
UMLS CUI : C1882264;
Semantic type(s)
- concept_is_in_subset
- has_target
