Preferred Label : PSMA-specific Targeting Module TMpPSMA;
NCIt synonyms : TMpPSMA; PSMA Peptide Target Module TMpPSMA; PSMA-specific TM TMpPSMA;
NCIt definition : A preparation of soluble adapter molecules consisting of an antigen-binding moiety
targeting the tumor-associated antigen (TAA) human prostate-specific membrane antigen
(PSMA), linked to a peptide motif recognizable by UniCAR02-T, that may be used to
activate UniCAR02-T. Upon administration of PSMA-specific targeting module (TM) TMpPSMA,
and upon co-administration of UniCAR02-T, the antigen-binding moiety of TMpPSMA targets
and binds to cancer cells expressing PSMA, and the binding domain of UniCAR02-T binds
to the nuclear antigen motif of TMpPSMA. This activates UniCAR02-T, and induces selective
toxicity in and causes lysis of PSMA-expressing tumor cells. PSMA is overexpressed
on the surface of metastatic and hormone-refractory prostate cancer cells.;
NCI Metathesaurus CUI : CL1661974;
Origin ID : C179342;
UMLS CUI : C5555624;
Semantic type(s)
- concept_is_in_subset
- has_target
