Lutetium Lu 177 Vipivotide Tetraxetan

Preferred Label : Lutetium Lu 177 Vipivotide Tetraxetan;

NCIt synonyms : 177Lu-PSMA-617; Lu177-PSMA-617; 177Lu-labeled PSMA-617; Lutetium Lu 177-PSMA-617; Lutetium-177-PSMA-617;

NCIt related terms : LUTETIUM LU-177 VIPIVOTIDE TETRAXETAN;

NCIt definition : A radioconjugate composed of PSMA-617, a human prostate-specific membrane antigen (PSMA)-targeting ligand, conjugated to the beta-emitting radioisotope lutetium Lu 177 (177Lu), with potential antineoplastic activity against PSMA-expressing tumor cells. Upon intravenous administration of lutetium Lu 177 vipivotide tetraxetan, vipivotide tetraxetan targets and binds to PSMA-expressing tumor cells. Upon binding, PSMA-expressing tumor cells are destroyed by 177Lu through the specific delivery of beta particle radiation. PSMA, a tumor-associated antigen and type II transmembrane protein, is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate tumor cells.;

UNII : G6UF363ECX;

InChIKey : RSTDSVVLNYFDHY-BGOLSCJMSA-K;

CAS number : 1703749-62-5; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1703749-62-5 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Pluvicto;

Molecule name : AAA-617; AAA 617;

NCI Metathesaurus CUI : CL550803;

Codes from synonyms : 68645;

Details

Origin ID

C148145;

UMLS CUI

C4308025;

Currated CISMeF NLP mapping
- 177Lu-PSMA-617 [MeSH Supplementary Concept]
- 177Lu-PSMA-617 [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- 177Lu-PSMA-617 [MeSH Supplementary Concept]
- Lutetium (177-Lu) vipivotide tetraxetan (substance) [SNOMED CT concept]
- lutetium (177Lu) vipivotide tetraxetan [ATC Code]
Validated automatic mappings to BTNT
- lutetium (177Lu) vipivotide tetraxetan [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glutamate Carboxypeptidase 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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