Preferred Label : Lutetium Lu 177 Rosopatamab Tetraxetan;
NCIt synonyms : Lu 177 MOAB J591; 177Lu-DOTA-TLX591; Lutetium Lu 177-DOTA-TLX591; Lutetium Lu 177-DOTA-Rosopatamab; Lutetium Lu 177 Monoclonal Antibody J591; DOTA-HUJ-591 LU-177; Lutetium Lu 177 Rosopatamab;
NCIt related terms : ROSOPATAMAB TETRAXETAN LUTETIUM LU-177;
NCIt definition : A radioimmunoconjugate consisting of rosopatamab, a humanized monoclonal antibody
(MoAb) against the external domain of the prostate-specific membrane antigen (PSMA)
that is linked, via the chelating agent, dodecanetetraacetic acid (DOTA), to the beta-emitting
radioisotope lutetium Lu 177, with potential antineoplastic activity and imaging activity
during single-photon emission computerized tomography/computerized tomography (SPECT/CT).
Upon administration, lutetium Lu 177 rosopatamab tetraxetan binds to PSMA expressed
on certain tumor cells. Upon binding and internalization, this radioconjugate specifically
delivers a cytotoxic dose of beta radiation to PSMA-expressing cells. PSMA is overexpressed
in the malignant prostate and its metastases.;
UNII : JB9647672Z;
Origin ID : C38701;
UMLS CUI : C5557425;
Semantic type(s)
- concept_is_in_subset
- has_target
