Preferred Label : Copper Cu 67 SAR-bisPSMA;
NCIt synonyms : 67Cu SAR-bisPSMA; Copper Cu 67-SAR-bisPSMA; 67Cu-SAR-bisPSMA;
NCIt definition : A radioconjugate composed of two human prostate-specific membrane antigen (PSMA)-binding
motifs linked to a sarcophagine (SAR)-based chelator and radiolabeled with the beta-emitting
radioisotope copper Cu 67, with potential antineoplastic activity. Upon administration
of copper Cu 67 SAR-bisPSMA, the PSMA-binding motifs target and bind to PSMA-expressing
tumor cells, thereby delivering a cytotoxic dose of beta radiation to PSMA-expressing
tumor cells. PSMA, a tumor-associated antigen (TAA) and type II transmembrane protein,
is expressed on the membrane of prostatic epithelial cells and overexpressed on prostate
tumor cells as well as a variety of other solid tumors.;
NCI Metathesaurus CUI : CL1798430;
Origin ID : C189750;
UMLS CUI : C5708742;
Semantic type(s)
- concept_is_in_subset
- has_target
