Preferred Label : Copper Cu 67 Abefolastat Tesaroxetan;
NCIt synonyms : 67Cu SAR-bisPSMA; Copper Cu 67-SAR-bisPSMA; 67Cu-SAR-bisPSMA; SAR-BIS-PSMA Cu 67; Copper Cu 67 SAR-bisPSMA;
NCIt definition : A radioconjugate composed of abefolastat tesaroxetan, two human prostate-specific
membrane antigen (PSMA)-binding motifs linked to a sarcophagine (SAR)-based chelator
and radiolabeled with the beta-emitting radioisotope copper Cu 67, with potential
antineoplastic activity. Upon administration of copper Cu 67 abefolastat tesaroxetan,
the PSMA-binding motifs target and bind to PSMA-expressing tumor cells, thereby delivering
a cytotoxic dose of beta radiation to PSMA-expressing tumor cells. PSMA, a tumor-associated
antigen (TAA) and type II transmembrane protein, is expressed on the membrane of prostatic
epithelial cells and overexpressed on prostate tumor cells as well as a variety of
other solid tumors.;
NCI Metathesaurus CUI : CL1798430;
Origin ID : C189750;
UMLS CUI : C5708742;
Semantic type(s)
- concept_is_in_subset
- has_target
