Preferred Label : Zirconium Zr 89 Desferrioxamine B Monoclonal Antibody huJ591;
NCIt synonyms : 89Zr-DFO-huJ591;
NCIt definition : A radioimmunoconjugate comprised of the recombinant humanized monoclonal antibody
J591 against prostate-specific membrane antigen (PSMA) conjugated to chelator desferrioxamine
B (DFO-B) and labeled with the radioisotope zirconium Zr 89 with potential imaging
property used in positron emission tomography (PET) imaging. Upon administration of
zirconium Zr 89 desferrioxamine B monoclonal antibody huJ591, the antibody moiety
binds to the extracellular domain of PSMA, and the radioisotope moiety may be detected
using PET, thereby allowing the imaging and quantification of PSMA-expressing tumor
cells. PSMA, or folate hydrolase, is a cell surface peptidase highly expressed by
malignant prostate epithelial cells and vascular endothelial cells of numerous solid
tumor malignancies. In addition, upon PET imaging this agent provides high tumor:background
tissue ratios.;
NCI Metathesaurus CUI : CL433986;
Origin ID : C101133;
UMLS CUI : C3640000;
Semantic type(s)
- concept_is_in_subset
- has_target
