Preferred Label : Anti-GD2 Antibody-drug Conjugate M3554;
NCIt synonyms : Anti-GD2 ADC M3554; Anti-GD2/Exatecan ADC M3554;
NCIt definition : An antibody-drug conjugate (ADC) composed of the humanized monoclonal antibody dinutuximab
(ch14.18) directed against the tumor-associated antigen (TAA) disialoganglioside (GD2;
GD-2) conjugated, via a cleavable beta-glucuronide linker, to the camptothecin analog
and topoisomerase 1 inhibitor exatecan, with potential antineoplastic activity. Upon
administration of anti-GD2 ADC M3554, dinutuximab targets and binds to GD2 expressed
on tumor cells. Upon binding, internalization and linker cleavage, exatecan is released.
Exatecan inhibits DNA topoisomerase 1 activity, thereby inhibiting DNA replication
and resulting in cell cycle arrest and tumor cell apoptosis. This inhibits the proliferation
of GD2-expressing tumor cells. GD2 is overexpressed in certain tumor types including
neuroblastoma, osteosarcoma, glioma and soft tissue sarcoma.;
Molecule name : M-3554; M 3554;
Origin ID : C212045;
concept_is_in_subset
- has_target
