Preferred Label : Anti-GD2 scFv/Anti-DOTA scFv Fusion Protein GD2-SADA;
NCIt synonyms : Anti-GD2 scFv/Anti-DOTA scFv/SADA Domain Fusion Protein GD2-SADA;
NCIt definition : A fusion protein composed of a single chain variable fragment (scFv) targeting the
tumor-associated antigen (TAA) and disialoganglioside GD2, an scFv targeting the chelating
agent 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) and a self-assembling
and disassembling (SADA) domain that can self-assemble from a monomeric polypeptide
into tetrameric protein, that may be used as a pre-targeted radioimmunotherapeutic
agent. Upon administration, anti-GD2 scFv/anti-DOTA scFv fusion protein GD2-SADA assembles
in tetramers and the anti-GD2 scFv binds to GD2-expressing tumor cells. The unbound
GD2-SADA is excreted. Upon administration of a DOTA-based radioactive payload, the
anti-DOTA scFv binds to the DOTA moiety of the radioactive payload, and radiation
is selectively delivered to tumor cells expressing GD2. GD2, a disialoganglioside
with expression in normal tissues restricted primarily to the cerebellum and peripheral
nerves, is commonly expressed at high levels on tumors of neuroectodermal origins
such as melanomas and neuroblastomas.;
Molecule name : GD2-SADA;
NCI Metathesaurus CUI : CL1799297;
Origin ID : C190828;
UMLS CUI : C5783950;
Semantic type(s)
- concept_is_in_subset
- has_target
