NCIt definition : HLA class II DR beta chain proteins (26-28 kD) form heterodimers with alpha (DRA)
chains, both anchored in the membrane. Expressed in antigen presenting cells (B lymphocytes,
dendritic cells, macrophages), alpha/beta heterodimers present peptides derived from
extracellular proteins. Hundreds of DRB alleles have been described and typing for
these polymorphisms is done for transplantation. (NCI);