NCIt definition : An agonistic, recombinant, humanized, hexavalent immunoglobulin G (IgG) antibody targeting
the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily
member 4; TNFRSF4), with potential immunostimulatory and antineoplastic activities.
Upon administration, ordastobart selectively binds to six OX40 receptors per molecule,
thereby clustering and activating OX40. This induces the proliferation of memory and
effector T-lymphocytes and results in a T-cell-mediated immune response against tumor
cells, which leads to tumor cell lysis. OX40, a cell surface glycoprotein and member
of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes
and provides a co-stimulatory signal that promotes both the proliferation and survival
of activated T-cells. Utilizing a hexavalent OX40 antibody may improve receptor clustering
and downstream signaling over tetravalent or bivalent OX40 antibodies.;
UNII : ZP8ENC5W1B;
CAS number : 2708115-83-5;
Molecule name : ES-102; ES 102; INBRX 106; INBRX-106;