NCIt definition : An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the
co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member
4; TNFRSF4), with potential immunomodulatory and antineoplastic activities. Upon administration,
anti-OX40 agonist monoclonal antibody HFB301001 selectively targets and binds to a
unique epitope on OX40, and activates OX40 without competing with the endogenous OX40
ligand (OX40L; tumor necrosis factor ligand superfamily member 4; TNFSF4). This may
induce the proliferation of memory and effector T-lymphocytes and inhibit the function
of T-regulatory cells (Tregs) in the tumor microenvironment (TME), thereby enhancing
anti-tumor immune responses and preventing Tregs-mediated immune suppression. OX40,
a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily
(TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation
and differentiation. HFB301001 does not lead to a downregulation of OX40 following
the co-stimulation of T-cells.;