" /> Nuvustotug - CISMeF





Preferred Label : Nuvustotug;

NCIt synonyms : Agonistic Anti-OX40 Monoclonal Antibody HFB301001; Anti-OX40 Agonist Monoclonal Antibody HFB301001;

NCIt definition : An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunomodulatory and antineoplastic activities. Upon administration, nuvustotug selectively targets and binds to a unique epitope on OX40, and activates OX40 without competing with the endogenous OX40 ligand (OX40L; tumor necrosis factor ligand superfamily member 4; TNFSF4). This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME), thereby enhancing anti-tumor immune responses and preventing Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation. HFB301001 does not lead to a downregulation of OX40 following the co-stimulation of T-cells.;

UNII : TA3CUZ8Y5M;

CAS number : 2916519-49-6;

Molecule name : HFB-301001; HFB 301001;

NCI Metathesaurus CUI : CL1792206;

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20/08/2025


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