NCIt definition : An agonistic human immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the
co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member
4; TNFRSF4), with potential immunomodulatory and antineoplastic activities. Upon administration,
nuvustotug selectively targets and binds to a unique epitope on OX40, and activates
OX40 without competing with the endogenous OX40 ligand (OX40L; tumor necrosis factor
ligand superfamily member 4; TNFSF4). This may induce the proliferation of memory
and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs)
in the tumor microenvironment (TME), thereby enhancing anti-tumor immune responses
and preventing Tregs-mediated immune suppression. OX40, a cell surface glycoprotein
and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed
on T-lymphocytes and plays an essential role in T-cell activation and differentiation.
HFB301001 does not lead to a downregulation of OX40 following the co-stimulation of
T-cells.;