" /> Cixutumumab - CISMeF





Preferred Label : Cixutumumab;

NCIt synonyms : Anti-IGF-1R Recombinant Monoclonal Antibody IMC-A12;

NCIt related terms : IMC-A12;

NCIt definition : A fully human IgG1 monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R) with potential antineoplastic activity. Cixutumumab selectively binds to membrane-bound IGF-1R, thereby preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signaling pathway. Downregulation of the PI3K/AKT survival pathway may result in the induction of cancer cell apoptosis and may decrease cancer cellular proliferation. IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by many cancer cell types, stimulates cell proliferation, enables oncogenic transformation, and suppresses apoptosis; IGF-1R signaling has been implicated in tumorigenesis and metastasis.;

Alternative definition : NCI-GLOSS: A substance being studied in the treatment of some types of cancer. It is a monoclonal antibody that is made in the laboratory and can bind to substances in the body. Cixutumumab blocks the action of a protein needed for cell growth and may kill cancer cells. It is a type of insulin-like growth factor-1 receptor (IGF-1R) inhibitor.;

UNII : 2285XW22DR;

CAS number : 947687-12-9;

Molecule name : IMC-A12; IMC A12;

Codes from synonyms : CDR0000644304; CDR0000644305; 106;

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08/05/2025


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