" /> Alemtuzumab - CISMeF





Preferred Label : Alemtuzumab;

NCIt related terms : Campath-1H;

NCIt definition : A recombinant DNA-derived humanized monoclonal antibody directed against the cell surface glycoprotein, CD52. Alemtuzumab is an IgG1 kappa with human variable framework and constant regions, and complementarity-determining regions derived from a rat monoclonal antibody. This agent selectively binds to CD52, thereby triggering a host immune response that results in lysis of CD52 cells. CD52 is a glycoprotein expressed on the surface of essentially all normal and malignant B and T cells, a majority of monocytes, macrophages and natural killer (NK) cells, a subpopulation of granulocytes, and tissues of the male reproductive system. (NCI04);

Alternative definition : NCI-GLOSS: A type of monoclonal antibody used in the treatment of leukemia. Monoclonal antibodies are laboratory-produced substances that can locate and bind to cancer cells.;

UNII : 3A189DH42V;

CAS number : 216503-57-0;

Drug name : MabCampath; Campath; Lemtrada; Campath-1H;

Molecule name : LDP-03; LDP 03;

NSC code : 715969;

Codes from synonyms : CDR0000044002; CDR0000044851; 17;

Details


Keyword's position in hierarchy(ies) : arborescence

You can consult :


Nous contacter.
30/05/2025


[Home] [Top]

© Rouen University Hospital. Any partial or total use of this material must mention the source.