" /> Anti-CD137 Agonistic Monoclonal Antibody ADG106 - CISMeF





Preferred Label : Anti-CD137 Agonistic Monoclonal Antibody ADG106;

NCIt synonyms : Anti-4-1BB Agonistic Monoclonal Antibody ADG106; ADG 106; CD137-directed Agonistic Monoclonal Antibody ADG106; 4-1BB-directed Agonistic Monoclonal Antibody ADG106;

NCIt related terms : ADG-106;

NCIt definition : A human agonistic monoclonal antibody targeting CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating activity. Upon administration, anti-CD137 agonistic monoclonal antibody ADG106 binds to and activates CD137 expressed on a variety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces cytokine production and promotes T-cell mediated anti-tumor immune responses. CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.;

UNII : I4QM8E7Y2R;

Molecule name : ADG-106;

NCI Metathesaurus CUI : CL969811;

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15/05/2024


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