" /> Tigatuzumab - CISMeF





Preferred Label : Tigatuzumab;

NCIt synonyms : Anti-TRAIL-R2 MoAb; Anti-DR5 MoAb; anti-[Homo sapiens TNFRSF10B (Tumor Necrosis Factor Receptor Superfamily Member 10B, DR5, TRAIL-R2, CD262)] Humanized Monoclonal TRA-8;

NCIt definition : A humanized agonistic monoclonal antibody directed against human tumor necrosis factor-related apoptosis-inducing ligand receptor 2 (TRAIL-R2) with potential antitumor activity. Mimicking the natural receptor ligand TRAIL, tigatuzumab binds to TRAIL-R2, activating signal transduction pathways that may result in tumor cell apoptosis and a reduction in tumor growth. A member of the tumor necrosis factor (TNF) receptor family, TRAIL-R2, also known as DR5 (death receptor 5), is expressed on the surfaces of many types of malignant cells.;

UNII : 237GB6IDKO;

CAS number : 918127-53-4;

Molecule name : CS-1008; CS 1008;

Codes from synonyms : 494;

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31/05/2025


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