NCIt definition : A humanized agonistic monoclonal antibody targeting the costimulatory receptor CD137
(4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential
immunostimulating and antineoplastic activities. Upon administration, anti-CD137 agonistic
monoclonal antibody EU101 targets and binds to CD137 expressed on a variety of leukocyte
subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances
CD137-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine
production and promotes a CTL-mediated anti-tumor immune response as well as induces
NK-mediated tumor cell killing and suppresses the immunosuppressive activity of regulatory
T-cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor
superfamily, is an inducible costimulatory receptor that plays a key role in T-cell
proliferation, survival and cytolytic activity.;