Enoticumab - CISMeF

Preferred Label : Enoticumab;

NCIt synonyms : Anti-Delta-Like 4 Monoclonal Antibody REGN421; Anti-Dll4 Monoclonal Antibody REGN421;

NCIt definition : A human monoclonal antibody directed against Delta-like ligand-4 (DLL4) with potential antineoplastic activity. Enoticumab specifically binds to human DLL4, preventing its binding to Notch receptors and inhibiting Notch signaling, which may result in defective tumor vascularization and, so, the inhibition of tumor cell growth. DLL4 is the only Notch ligand selectively expressed on endothelial cells; DLL4/Notch signaling is required for the development of functional tumor blood vessels.;

UNII : B59DCD0F7D;

CAS number : 1192578-27-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1192578-27-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : REGN421; SAR153192;

Details

Origin ID

C82367;

UMLS CUI

C4045642;

Automatic exact mappings (from CISMeF team)
- REGN421 [MeSH concept]
- enoticumab [MeSH concept]
Currated CISMeF NLP mapping
- enoticumab [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- enoticumab [MeSH Supplementary Concept]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Antibody-Dependent Cellular Cytotoxicity [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Delta-Like Protein 4 [NCIt concept]

Keyword's position in hierarchy(ies) :

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