Delta-Like Protein 4

Preferred Label : Delta-Like Protein 4;

NCIt synonyms : Drosophila Delta Homolog 4; Delta4; DLL4;

NCIt definition : Delta-like protein 4 (685 aa, 75 kDa) is encoded by the human DLL4 gene. This protein is involved in the initiation of notch signaling.;

NCIt note : Antibodies against Delta-like protein 4 are being studied as post-surgery vaccines against cancer relapse.;

Details

Origin ID

C90319;

UMLS CUI

C2983553;

OMIM relation
- Delta-like canonical notch ligand 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DLL4 Gene [NCIt concept]
- Signaling Pathway Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Notch Proteolysis and Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Blood Circulation [NCIt concept]
- Cell Differentiation Process [NCIt concept]
- Ligand Binding [NCIt concept]
- Signal Transduction [NCIt concept]
is_target
- Anti-DLL4 Monoclonal Antibody MEDI0639 [NCIt concept]
- Anti-DLL4/Anti-VEGF-A Bispecific Antibody CTX-009 [NCIt concept]
- Demcizumab [NCIt concept]
- Dilpacimab [NCIt concept]
- Enoticumab [NCIt concept]
- Navicixizumab [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients