" /> Demcizumab - CISMeF





Preferred Label : Demcizumab;

NCIt synonyms : Anti-Delta-like 4 Monoclonal Antibody OMP-21M18; Anti-DLL4 Monoclonal Antibody OMP-21M18;

NCIt definition : A humanized monoclonal antibody directed against the N-terminal epitope of Notch ligand DLL4 (delta-like 4) with potential antineoplastic activity. Demcizumab binds to the membrane-binding portion of DLL4 and prevents its interaction with Notch-1 and Notch-4 receptors, thereby inhibiting Notch-mediated signaling and gene transcription, which may impede tumor angiogenesis. Activation of Notch receptors by DLL4 stimulates proteolytic cleavage of the Notch intracellular domain (NICD); after cleavage, NICD is translocated into the nucleus and mediates the transcriptional regulation of a variety of genes involved in vascular development. The expression of DLL4 is highly restricted to the vascular endothelium.;

UNII : SF168W7FW0;

CAS number : 1243262-17-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1243262-17-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : OMP-21M18;

Chemical formula : 1243262-17-0;

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15/05/2024


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