Interferon Gamma-1b

Preferred Label : Interferon Gamma-1b;

NCIt synonyms : Recombinant Interferon Gamma-1b; N(Sup 2)-L-Methionyl-1-139-Interferon G; IFN-gamma 1b; IFN-g-1b; IFNg-1b; N(sup 2)-L-Methionyl-1-139-interferon gamma (Human Lymphocyte Protein Moiety Reduced); Interferon gamma-1b, Recombinant; gamma Interferon 1B;

NCIt definition : A recombinant form of the endogenous cytokine human interferon (IFN) gamma-1b, with immunomodulating activity. Upon administration, IFN gamma-1b targets, binds to, and activates the cell-surface IFN-gamma receptor, stimulating antibody dependent cellular cytotoxicity (ADCC), activating natural killer (NK) cells, and enhancing the oxidative metabolism of macrophages. IFN-gamma plays important roles in the innate and adaptive immune responses.;

UNII : 21K6M2I7AG;

CAS number : 98059-61-1;

Drug name : Actimmune;

Codes from synonyms : 276;

Details

Origin ID

C100089;

UMLS CUI

C0021741;

Currated CISMeF NLP mapping
- Interferon gamma-1B [SMS substance]
- Interferon gamma-1b [MeSH concept]
- Interferon gamma-1b (substance) [SNOMED CT concept]
- interferon gamma-1b [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Interferon gamma-1b [MeSH concept]
- Interferon gamma-1b (substance) [SNOMED CT concept]
- Product containing interferon gamma-1b (medicinal product) [SNOMED CT concept]
- interferon gamma-1b [MeSH Supplementary Concept]
chemical_or_drug_affects_gene_product
- Interferon Gamma Receptor Complex [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Cytokine Receptor Activation [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Antibody-Dependent Cellular Cytotoxicity [NCIt concept]
- Immunopotentiation [NCIt concept]
- Inhibition of Cell Proliferation [NCIt concept]
- Positive Regulation of Apoptosis [NCIt concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
is_component_of_chemotherapy_regimen
- Interferon gamma-1b Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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