Interferon Gamma Receptor Complex

Preferred Label : Interferon Gamma Receptor Complex;

NCIt synonyms : IFN-Gamma Receptor;

NCIt definition : Expressed in monocytes, lymphocytes, and placenta, human Interferon Gamma Receptor Complex (Type II Cytokine Family Receptor) is a Ser/Thr phosphorylated type I membrane protein heteromeric receptor for IFN-gamma, composed of IFNGR1 and IFNGR2, that activates macrophages in host defenses. In mediating innate immune responses to viral infection, binding of IFN-gamma activates JAK kinases leading to tyrosine phosphorylation of STAT1 and STAT2. IFNGR1 constitutes the receptor ligand-binding alpha chain while the integral accessory factor IFNGR2 is required for signal transduction and may interact with GAF, JAK1, and/or JAK2. (NCI);

NCIt note : Protein_Plays_Role_In_Biological_Process: Macrophage Activation;

Details

Origin ID

C37279;

UMLS CUI

C1334197;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
gene_product_affected_by_chemical_or_drug
- Interferon Gamma-1a [NCIt concept]
- Interferon Gamma-1b [NCIt concept]
- Recombinant Interferon Gamma [NCIt concept]
gene_product_has_biochemical_function
- Cytokine Receptor [NCIt concept]
gene_product_plays_role_in_biological_process
- Antiviral Response [NCIt concept]
- Receptor Signaling [NCIt concept]
- Serine/Threonine Phosphorylation [NCIt concept]
has_gene_product_element
- Interferon Gamma Receptor 1 [NCIt concept]
- Interferon Gamma Receptor 2 [NCIt concept]

Keyword's position in hierarchy(ies) :

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