NCIt definition : An agonistic humanized immunoglobulin G1 (IgG1) monoclonal antibody against the cell
surface receptor OX40 (CD134; TNFRSF4), with potential immune checkpoint inhibitory
and antineoplastic activities. Upon administration, anti-OX40 monoclonal antibody
GSK3174998 selectively binds to and activates OX40. Receptor activation induces proliferation
of memory and effector T-lymphocytes and results in a T-cell-mediated immune response
against tumor cells, which leads to tumor cell lysis. OX40, a cell surface glycoprotein
and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed
on T-lymphocytes and provides a co-stimulatory signal that promotes both the proliferation
and survival of activated T-cells.;