" /> Cenzestotug - CISMeF





Preferred Label : Cenzestotug;

NCIt synonyms : Agonistic Anti-OX40 Monoclonal Antibody YH-002; Anti-OX40 Agonist Monoclonal Antibody YH-002;

NCIt definition : An agonistic recombinant humanized immunoglobulin G1 (IgG1) monoclonal antibody that recognizes the co-stimulatory receptor OX40 (CD134; tumor necrosis factor receptor superfamily member 4; TNFRSF4), with potential immunostimulatory activity. Upon administration, cenzestotug selectively targets, binds to and activates OX40. This may induce the proliferation of memory and effector T-lymphocytes and inhibit the function of T-regulatory cells (Tregs) in the tumor microenvironment (TME). This enhances anti-tumor immune responses and prevents Tregs-mediated immune suppression. OX40, a cell surface glycoprotein and member of the tumor necrosis factor receptor superfamily (TNFRSF), is expressed on T-lymphocytes and plays an essential role in T-cell activation and differentiation.;

UNII : ZZ9BQY81L0;

CAS number : 3014361-58-8;

Molecule name : YH-002; YH 002;

NCI Metathesaurus CUI : CL1642928;

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20/08/2025


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