Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102

Preferred Label : Anti-Lewis B/Lewis Y Monoclonal Antibody GNX102;

NCIt synonyms : Anti-branched Lewis B/Lewis Y Monoclonal Antibody GNX102; Anti-LeB/LeY Monoclonal Antibody GNX102;

NCIt definition : A humanized monoclonal antibody directed against human tumor-associated carbohydrate antigens (TACAs) Lewis B (LeB) and Lewis Y (LeY), with potential antineoplastic activity. Upon administration, anti-LeB/LeY monoclonal antibody GNX102 binds to branched LeB and LeY glycans, which may induce an antibody-dependent cellular cytotoxicity (ADCC) response against LeB- and LeY-expressing tumor cells. LeB and LeY antigens, tetrasaccharides with low to moderate expression in monomeric form in normal adult tissues, is overexpressed in branched form in multiple forms of cancers.;

Molecule name : GNX-102; GNX 102;

NCI Metathesaurus CUI : CL1412719;

Details

Origin ID

C175411;

UMLS CUI

C5446501;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
chemical_or_drug_has_mechanism_of_action
- Antigen Binding [NCIt concept]
chemical_or_drug_has_physiologic_effect
- Antibody-Dependent Cellular Cytotoxicity [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Lewis Y Antigen [NCIt concept]
- Mucin-5AC [NCIt concept]

Keyword's position in hierarchy(ies) :

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