Preferred Label : Lenzilumab;
NCIt synonyms : Immunoglobulin G1-kappa, Anti-(Homo sapiens CSF2 (Colony Stimulating Factor 2 (Granulocyte-Macrophage),
Granulocyte Macrophage Colony Stimulating Factor, GM-CSF)), Homo sapiens Monoclonal
Antibody;
NCIt definition : A recombinant monoclonal antibody against the cytokine granulocyte macrophage colony-stimulating
factor (GM-CSF), with potential immunomodulating activity. Upon administration, lenzilumab
binds to and neutralizes GM-CSF. This prevents GM-CSF binding to the GM-CSF receptor,
which is a heterodimeric protein expressed on myeloid progenitor cells, and prevents
GM-CSF-mediated signaling. This may induce apoptosis in and inhibit proliferation
of cancer cells that overproduce GM-CSF. GM-CSF plays a key role in the differentiation
and proliferation of monocytes, macrophages and granulocytes; elevated levels of GM-CSF
are associated with certain autoimmune diseases, inflammatory diseases, and cancers.;
UNII : IE4X6497XK;
CAS number : 1229575-09-0;
Molecule name : KB 003; KB003;
NCI Metathesaurus CUI : CL503921;
Origin ID : C125081;
UMLS CUI : C4087043;
Automatic exact mappings (from CISMeF team)
- Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- chemical_or_drug_affects_cell_type_or_tissue
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
