Preferred Label : antibody-dependent cell cytotoxicity;
MeSH definition : The phenomenon of antibody-mediated target cell destruction by non-sensitized effector
cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN
G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors.
It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage,
or polynuclear leukocyte, depending on the identity of the target cell. The reaction
is complement-independent.;
MeSH synonym : cell cytoxicity, antibody-dependent; antibody-dependent cell cytoxicity; cell cytoxicity, antibody dependent; cytoxicity, antibody-dependent cell; adcc; antibody-dependent cell cytotoxicities; cell cytotoxicity, antibody-dependent; cytotoxicity, antibody dependent cell; antibody-dependent cell cytoxicities; cell cytotoxicities, antibody-dependent; cell cytoxicities, antibody-dependent; cytotoxicities, antibody-dependent cell; cytotoxicity, antibody-dependent cell; cytoxicities, antibody-dependent cell; antibody dependent cell cytotoxicity;
MeSH annotation : DF: note short X ref;
Wikipedia link : https://en.wikipedia.org/wiki/Antibody-dependent cell cytotoxicity;
Origin ID : D000920;
UMLS CUI : C0003272;
Allowable qualifiers
- Automatic exact mappings (from CISMeF team)
- Record concept(s)
- Semantic type(s)
- UMLS correspondences (same concept)
The phenomenon of antibody-mediated target cell destruction by non-sensitized effector
cells. The identity of the target cell varies, but it must possess surface IMMUNOGLOBULIN
G whose Fc portion is intact. The effector cell is a killer cell possessing Fc receptors.
It may be a lymphocyte lacking conventional B- or T-cell markers, or a monocyte, macrophage,
or polynuclear leukocyte, depending on the identity of the target cell. The reaction
is complement-independent.
