" /> Veligrotug - CISMeF





Preferred Label : Veligrotug;

NCIt synonyms : anti-CD122 monoclonal antibody AVE1642; Anti-IGF-1R Monoclonal Antibody AVE1642;

NCIt definition : A humanized monoclonal antibody directed against the human insulin-like growth factor-1 receptor (IGF-1R/CD221) with potential antineoplastic activity. Veligrotug specifically binds to and blocks membrane-bound IGF-1R, preventing the binding of the natural ligand IGF-1 and the subsequent activation of PI3K/AKT signal transduction, which may result in the induction of apoptosis and a decrease in cellular proliferation. Activation of IGF-1R, a receptor tyrosine kinase of the insulin receptor superfamily overexpressed by various cancer cell types, stimulates cell proliferation, promotes angiogenesis, enables oncogenic transformation, and suppresses apoptosis.;

UNII : Z9U2SS9ZC8;

CAS number : 1242567-05-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1242567-05-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AVE-1642;

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15/05/2024


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