Preferred Label : Cetuximab-loaded Ethylcellulose Polymeric Nanoparticles Decorated with Octreotide;
NCIt synonyms : Polymeric Nanoparticles Loaded With Cetuximab and Decorated With Octreotide; Cetuximab-loaded Polymeric Nanoparticles Decorated With Octreotide;
NCIt definition : A preparation of ethylcellulose polymeric nanoparticles loaded with cetuximab, a recombinant,
chimeric monoclonal antibody directed against the epidermal growth factor (EGFR),
and decorated with the somatostatin analog, octreotide, with potential antineoplastic
activity. Upon oral administration, the octreotide moiety directs the nanoparticles,
which remain inert until a pH of 6.8 is reached, to somatostatin receptors (SSTRs),
which are present on the cell membranes of many neuroendocrine tumor (NET) cells.
At this pH, cetuximab is selectively released from the ethylcellulose polymer. Cetuximab
may then bind to the extracellular domain of EGFR-expressing tumor cells, thereby
preventing the activation and subsequent dimerization of the receptor. This may inhibit
signal transduction and inhibit tumor cell proliferation in EGFR-dependent tumor cells.
EGFR, a member of the EGFR receptor tyrosine kinase family, may be overexpressed on
the cell surfaces of various tumor types.;
NCI Metathesaurus CUI : CL937696;
Origin ID : C158083;
UMLS CUI : C4764034;
Semantic type(s)
- chemical_or_drug_affects_gene_product
- chemical_or_drug_has_mechanism_of_action
- chemical_or_drug_has_physiologic_effect
- concept_is_in_subset
- has_target
