" /> Exlinkibart - CISMeF





Preferred Label : Exlinkibart;

NCIt synonyms : Anti-4-1BB Agonistic Monoclonal Antibody LVGN6051; Anti-CD137 Monoclonal Antibody LVGN6051; Anti-CD137 Agonist Monoclonal Antibody LVGN6051; Anti-CD137 Agonistic Monoclonal Antibody LVGN6051;

NCIt definition : A humanized agonistic monoclonal antibody targeting the costimulatory receptor CD137 (4-1BB; tumor necrosis factor receptor superfamily member 9; TNFRSF9), with potential immunostimulating and antineoplastic activities. Upon administration, exlinkibart targets and binds to CD137, thereby activating CD137 expressed on avariety of leukocyte subsets including activated T-lymphocytes and natural killer (NK) cells. This enhances CD137-mediated signaling, induces cytotoxic T-lymphocyte (CTL) proliferation, cytokine production and promotes a CTL-mediated anti-tumor immune response as well as induces NK-mediated tumor cell killing and suppresses the immunosuppressive activity of T-regulatory cells (Tregs). CD137, a surface glycoprotein of the tumor necrosis factor receptor superfamily, is an inducible costimulatory receptor that plays a key role in T-cell proliferation, survival and cytolytic activity.;

UNII : 23C7TO9S06;

CAS number : 2642171-64-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 2642171-64-8 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : LVGN-6051; LVGN 6051;

NCI Metathesaurus CUI : CL1405761;

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08/05/2024


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